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Research and Practice of Meta-synthesis Management for the Government-led Urban Complex Construction

Ru-gui Chen,Jia-meng Chen

《工程管理前沿（英文）》 2014年第1卷第1期页码 52-61 doi: 10.15302/J-FEM-2014008

摘要： This paper researches the overall construction target of government-led urban complex construction projects based on the perspective of sustainable urban development.In order to achieve benefit maximization, the meta-synthesis management for the government-led urban complex construction project is studied.In order to combine theory and practice, several typical government-led urban complex construction project cases, such as Guangzhou Higher Education Mega Center and Guangzhou International Financial City etc. areexamined. These examples point to thefeasibility of government-led meta-synthesis management and demonstrate the benefits that can be achieved through this model.

关键词： government-led construction project urban complex meta-synthesis management sustainable development benefit maximization

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Research on the Giant and Complex Financial Information System Engineering Management from the Perspectiveof Meta-synthesis Methodology—with the Bank Card Information Exchange System Engineering as a Sample

Hong-feng Chai,Quan Sun

《工程管理前沿（英文）》 2016年第3卷第4期页码 404-413 doi: 10.15302/J-FEM-2016037

摘要： The paper empirically studies the engineering practices of the national currency circulation information system-China Union Pay’s Bankcard Information Exchange System. By integrating the meta-synthesis methodology and the financial information system engineering, the paper proposes basic principles and processes of the giant and complex financial information system engineering management, and further explores its paradigm and toolkit.

关键词： financial information system meta-synthesis methodology bank card information exchange

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Meta-synthesis management framework of a complex project: A case study of the deck pavement project of

Qiang MAI, Xing-lin GAO, Shi AN, Ding LIU, Ming LIU

《工程管理前沿（英文）》 2018年第5卷第1期页码 4-16 doi: 10.15302/J-FEM-2018076

摘要： Innovative technology and deep uncertainty during the design and construction process of complex projects introduce great challenges to their organization and management. The traditional methods, represented in the project management body of knowledge (PMBOK) guide, can solve systematic problems; however, they cannot solve complex problems. Based on the management practice implemented in the deck pavement project of the Hong Kong-Zhuhai-Macao Bridge (HZMB), in this work, we propose a meta-synthesis management framework for a complex project from the perspective of the science of complexity. The method deems that the complexity of the project has the characteristic of being multi-scale both in the design phase and the construction phase. These problems can be classified into different categories, each of which requires a different strategy. As a result, it is first necessary to adopt the “exploration” strategy to reduce project complexity and to transform the deep uncertainty problems into systematic problems. Then, the “exploitation” strategy should be used to apply the PMBOK and other traditional methods to achieve the design and construction goals of the project and to improve its efficiency. More specifically, in the design phase of a complex project, the “innovative integration” process is used for the exploration of the new engineering technology and knowledge; then, the “functional integration” process is employed to define the system architecture, the interface relationship, the technical index, and other functions. In the construction phase, the “adaptive integration” process is used for the construction of the engineering organization system; next, the “efficient integration” process is employed to improve the actual construction performance. The meta-synthesis management framework proposed in this work reveals the multi-scale principle of solving complex problems in the management practice of a complex project, and develops the methodology of meta-synthesis.

关键词： complex project meta-synthesis management Hong Kong-Zhuhai-Macao Bridge exploration strategy exploitation strategy

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政府主导的城市综合体建设项目集成管理研究与实践

陈如桂,陈加猛

《中国工程科学》 2013年第15卷第11期页码 53-61

摘要：

本文立足于城市可持续发展的角度，研究政府主导的城市综合体建设项目总体建设目标定位；以综合效益最大化为导向，研究政府主导的城市综合体建设项目的综合集成管理；并遵循理论与实践相结合的方法，对广州大学城和广州国际金融城等政府主导的城市综合体建设项目典型案例进行实践和探索。

关键词：政府主导的建设项目城市综合体综合集成管理可持续发展效益最大化

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钱学森的现代科学技术体系与综合集成方法论

于景元

《中国工程科学》 2001年第3卷第11期页码 10-18

摘要：

文章介绍了钱学森提出的现代科学技术体系和综合集成方法论。现代科学技术体系是横向上由11个科学技术部门、纵向上由三个层次，即基础理论、技术科学和应用技术所构成的矩阵式结构；综合集成方法论是由“从定性到定量综合集成方法”和“从定性到定量综合集成研讨厅体系”所构成。文章还讨论了它们在实践中的应用。

关键词：钱学森现代科学技术体系综合集成方法

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综合集成方法的实践——“中国载人航天发展战略”研究方法总结

钱振业,杨广耀,韦德森,程玲珠

《中国工程科学》 2006年第8卷第12期页码 10-15

摘要：

中国要不要搞载人航天？怎么搞载人航天？采取何种发展战略和技术途径，涉及政治、经济、军事、社会和科技诸多方面。遵照钱学森院士创建的系统学提出的“定性与定量相结合的综合集成方法”，结合中国国情，以软科学命题，从指导思想、研究步骤和研究方法几方面进行了研究，研究结果表明，“面对世界载人航天的挑战和机遇，中国载人航天不可不搞，也不能大搞，飞船起步，平稳发展万无一失。盲自赶超或急于缩小差距均将陷入困境，疑虑过多以至坐视不顾，也会失掉机会和希望。”文章对该软科学命题做了总结。

关键词：决策研究综合集成飞船工程

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A global synthesis of the effectiveness and ecological impacts of management interventions for species

《环境科学与工程前沿（英文）》 2023年第17卷第11期 doi: 10.1007/s11783-023-1741-x

摘要：

● Spartina abundance decreases over time by chemical control.

关键词： Plant invasion Biodiversity Meta-analysis Restoration Salt marshes Treatment timing

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现代科学技术体系与大成智慧

戴汝为

《中国工程科学》 2008年第10卷第10期页码 4-8

摘要：

扼要地介绍了科学家钱学森提出的现代科学技术体系构思，并从现代科学技术体系出发对智能系统及大成智慧(meta-synthetic wisdom

关键词：现代科学技术体系大成智慧开放的复杂巨系统综合集成法思维科学

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“开放的复杂巨系统”概念的形成

卢明森

《中国工程科学》 2004年第6卷第5期页码 17-23

摘要：

根据已经公开发表的钱学森院士的讲话、文章和书信，在分析开放的复杂巨系统这个概念形成背景的基础上，重点考察了巨系统→复杂巨系统→开放的复杂巨系统的提炼过程，概括介绍了开放的复杂巨系统理论的基本内容，阐述了这个理论的形成对当前与今后的科学发展、尤其是对系统科学、思维科学-创新思维研究的重大意义。

关键词：巨系统复杂巨系统开放的复杂巨系统从定性到定量综合集成法系统科学思维科学

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独领风骚屹立群伦——评钱学森著《创建系统学》

冯国瑞

《中国工程科学》 2002年第4卷第8期页码 74-80

摘要：

文章从当代世界科学文化的大背景出发，通过比较，阐明了钱学森在现代科学技术特别是系统科学研究方面，在国内独领风骚，在国际屹立群伦；探讨了钱学森取得这一成就的深刻原因，论述了由此获得的思想启示。

关键词：现代科学系统科学系统学开放的复杂巨系统从定性到定量综合集成方法马克思主义哲学

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钱学森与控制论

郑应平

《中国工程科学》 2001年第3卷第10期页码 7-12

摘要：

文章首先介绍了控制论的内容、方法和意义, 以及历史回顾，并特别强调其在人类文明和科技发展中的重要地位，进而介绍了钱学森《工程控制论》的内容、观点及其在整个控制论发展过程中的承前启后作用，特别强调了它定位于面向工程应用的理论及其技术科学的特点，即把工程实际中行之有效的原理和方法整理总结成为理论，又将此理论在解决工程问题中不断充实、提高和发展。随着他结合系统工程和大系统、复杂系统乃至复杂巨系统的控制问题逐步形成的综合集成方法论体系，进一步明确了他对控制论在系统科学体系中的地位、作用和现代发展方向的观点，对现代控制论的发展起到了重要的推动作用。文中具体介绍了系统工程、系统科学体系和复杂系统控制理论的发展和融汇, 指出它们已成为当前科技迅猛发展的重要方面。最后简要介绍了当前信息科学全面发展的趋势，以及系统和控制理论在现代社会发展中的重要历史使命。

关键词：控制论工程控制论技术科学复杂系统控制复杂巨系统综合集成方法论

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Efficacy and safety of benralizumab in patients with eosinophilic asthma: a meta-analysis of randomized

null

《医学前沿（英文）》 2018年第12卷第3期页码 340-349 doi: 10.1007/s11684-017-0565-0

摘要：

Benralizumab is a monoclonal antibody that targets interleukin-5 receptor α to deplete blood eosinophils and improve the clinical outcomes of allergic asthma. We conducted a meta-analysis to evaluate the safety and efficacy of different doses of benralizumab in patients with eosinophilic asthma. All randomized controlled trials involving benralizumab treatment for patients with eosinophilic asthma, which were searched in PubMed, Embase, and the Cochrane Library published until January 2017, as well as the rate of asthmatic exacerbation, pulmonary functionality, asthma control, quality of life scores, and adverse events were included. Randomized-effect models were used in the meta-analysis to calculate the pooled mean difference, relative risks, and 95% confidence intervals. Five studies involving 1951 patients were identified. Compared with the placebo, benralizumab treatment demonstrated significant improvements in the forced expiratory volume in 1?s (FEV1), Asthma Quality of Life Questionnaire scores, decreased asthmatic exacerbation and Asthma Control Questionnaire-6 (ACQ-6) scores. Benralizumab treatment was also not associated with increased adverse events. These findings indicated that benralizumab can be safely used to improve FEV1, enhance patient symptom control and quality of life, and reduce the risk of exacerbations and ACQ-6 scores in patients with eosinophilic asthma. Furthermore, our meta-analysis showed that benralizumab with 30 mg (every eight weeks) dosage can improve the health-related quality of life and appear to be more effective than 30 mg (every four weeks) dosage. Overall, data indicated that the optimal dosing regimen for benralizumab was possibly 30 mg (every eight weeks).

关键词： benralizumab anti-interleukin-5 monoclonal antibody eosinophilic asthma meta-analysis

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Association between telomere length and survival in cancer patients: a meta-analysis and review of literature

null

《医学前沿（英文）》 2016年第10卷第2期页码 191-203 doi: 10.1007/s11684-016-0450-2

摘要：

The relationship between telomere length and cancer survival has been widely studied. To gain a deeper insight, we reviewed the published studies. A total of 29 studies evaluated telomere length in the peripheral blood; 22 studies evaluated telomere length in the tumor tissue. First, in the peripheral blood studies, for solid tumor patients with shortened telomere length, the combined hazard ratios (HRs) for mortality and tumor progression were 1.21 (95%CI, 1.10–1.32) and 1.71 (95%CI, 1.37–2.13), respectively. Meanwhile, in hematology malignancy, the combined HRs for mortality and tumor progression were 2.83 (95%CI, 2.14–3.74) and 2.65 (95%CI, 2.18–3.22), respectively. Second, in the studies that use tumor tissue, for patients with shortened telomeres, the combined HRs for mortality and tumor progression were 1.26 (95%CI, 0.95–1.66) and 1.65 (95%CI, 1.26–2.15), respectively. In the studies that calculate the telomere length ratios of tumor tissue to adjacent normal mucosa, for patients with lower telomere length ratios, the combined HRs were 0.66 (95%CI, 0.53–0.83) and 0.74 (95%CI, 0.41–1.32) for mortality and tumor progression, respectively. In conclusion, shortened telomere in peripheral blood and tumor tissue might indicate poor survival for cancer patients. However, by calculating the telomere length ratios of tumor tissue to adjacent normal mucosa, the lower ratio might indicate better survival.

关键词： telomere survival cancer meta-analysis

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Treatment outcomes of pulmonary tuberculosis in the past decade in the mainland of China: a meta-analysis

null

《医学前沿（英文）》 2013年第7卷第3期页码 354-366 doi: 10.1007/s11684-013-0257-3

摘要：

Due to the implementation of directly observed treatment strategy (DOTS), China has made a significant achievement in tackling the tuberculosis (TB) epidemic in the 1990s. However, only half of regions in China met or exceeded the 85% rate of treatment success target. The aim of the present study is to summarize the treatment outcomes of smear-positive pulmonary TB in the mainland of China in the past decade using meta-analysis based on systematic review of published observational studies. A total of 50 eligible articles (58 studies) were identified and included in this study. The summarized treatment success rates were 93.9% (95% CI, 92.8%–94.7%) for new cases and 85.4% (95% CI, 83.0%–87.6%) for previously treated cases, and the summarized cured rate were 92.2% (95% CI, 90.9%–93.3%) and 81.2% (95% CI, 79.1%–83.1%), respectively. A remarkable increase of rates for treatment success and cure was observed in the 1990s. After 2000, the summarized treatment outcomes were tending towards stability. In addition, geographic areas, type of the data and administrative level of the hospital were also found to influence the estimates of the treatment outcomes. Results of the present study clearly show, in general, that the pulmonary TB treatment achieved significant success in the past decade in the mainland of China. However, it needs to be further strengthened in the central and west areas.

关键词： tuberculosis treatment outcome China meta-analysis

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An update and cumulative meta-analysis

null

《医学前沿（英文）》 2014年第8卷第2期页码 241-249 doi: 10.1007/s11684-014-0328-0

摘要：

Approximately 70% of newly diagnosed bladder tumors are non-muscle invasive bladder cancer (NMIBC). NMIBC accounts for approximately 80% of total bladder cancer cases. Bacillus Calmette-Guérin (BCG) instillation and maintenance is considered as the standard adjuvant treatment for superficial bladder cancer. A number of randomized studies have focused on the benefit of maintenance therapy following initial BCG induction. To provide further insights into the effect of intravesical instillation on recurrence in patients with NMIBC, we analyzed this relationship by conducting an updated detailed meta-analysis. Evidence suggested that adjuvant intravesical BCG with maintenance treatment is significantly effective for the prophylaxis of tumor recurrence in patients with NMIBC.

关键词： non-muscle invasive bladder cancer bacillus Calmette-Guérin (BCG) meta-analysis